CompChem Solutions offer the following research services:

Computational Chemistry
Medicinal Chemistry
IP Information Services
Pharmacology & ADME

Research: Computational Chemistry

Susan Boyd & Dorica Naylor have extensive experience in numerous therapeutic areas, gained within big pharma, biotech and academic research groups. Services offered include:

• Computational chemistry support for medicinal chemistry projects
• Library design service
• "Analogue-by-catalogue" similarity searches – sourcing can be arranged
• Chemoinformatics (e.g. SMARTS & SMILES handling, databases, application development etc)
• Advice on computational chemistry matters (software available, technology transfer opportunities etc)
• Creation of animated “videos” of computational chemistry simulations, for educational or promotional purposes (useful for presentations to investors!)
• Validation studies on software or methodology for evaluation purposes
• Training of chemists or computational chemists
• Marketing of computational chemistry to customers/partners
• Help with recruiting
• Maternity/illness cover

Research: Medicinal Chemistry

Andrea Walmsley & Ian Matthews collectively have around 40 years of industrial experience in medicinal chemistry behind them, gained in both big pharma and biotech environments. Services offered include:

• Synthetic route design
• Drug discovery program definition and design
• Fully independent assessment and management of chemistry CRO’s
• Management of Lead ID and Lead Optimisation programmes
• Medicinal Chemistry design of focused libraries
• Chemical modifications to improve ADME profiles/create novel compounds
• Assistance with patent drafting and strategy
• Assistance with compound storage and management.

Research: IP Information Services

Neil Walden began his career in IP information in 1987 with Rhone-Poulenc Rorer. He subsequently worked for both Pfizer and GSK before becoming an IP Information consultant in 2009. Services offered include:

• Patent searches in the areas of novelty, prior art, freedom to operate & infringement
• Markush chemical structure searching using STN, Marpat and MMS with analysis and presentation of results to agreed formats
• Reaction searches (CASREACT and other STN reaction databases)
• Chemical route FTO searches
• Text searching, including biological target searches for small molecule and biopharmaceutical discovery research
• Patent information retrieval (eg patent families, patent expiry data, legal status for major patent offices)
• Invalidity searches of hard copy sources (e.g. PhD theses and British Library documents and books)
• Text mining (e.g. Linguamatics)

Research: Pharmacology & ADME

Julie Warneck has 20 years industry experience in pharmaceutical R&D, spanning virtual biotech to medium sized pharma. Services offered include:

• Identification, selection and liaison with CROs for research models
• Full management of outsourced pharmacology & ADME studies
• Pharmacokinetic data analysis and modelling
• Assistance with development candidate nomination